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KMID : 0359319980380040946
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Korean Journal of Veterinary Research
1998 Volume.38 No. 4 p.946 ~ p.956
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Time relationship between the change of blood glucose concentration and the change of hemoglobin A1 concentration in experimentally induced diabetic dogs
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Abstract
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Fifteen mongrel dogs (14 male and 1 female) were injected intravenously with 30㎎ of streptozotocin and 50㎎ of alloxan monohydrate per kilogram of body weight to induce diabetes mellitus. Before treatment with streptozotocin and alloxan fasting serum glucose concentration was determined every other day or thrice a week (Monday, Wednesday, Friday) for 3 months. Among 15 dogs 4 dogs developed diabetes mellitus and survived more than 9 weeks without injection of insulin. After treatment fasting serum glucose and hemoglobin A₁ concentrations of the 4 dogs were determined every other day or thrice a week. Fasting serum glucose concentration increased acutely from 24 hours after treatment and then showed severe fluctuation. Hemoglobin A₁ concentration increased gradually until 7-9 weeks after treatment and then showed very slow increase afterwards. Correlation of hemoglobin A₁ to fasting glucose concentration was relatively weak(r = 0.10-0.80). Hemoglobin A₁ and fasting glucose concentration of preceding 7 week showed very high correlation (r = 0.98-0.99). It was indicated that hemoglobin A₁ concentration in chemically induced diabetic dogs reflects mean glucose concentration of preceding 7-9 weeks.
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